Description
Xitabin is a prodrug of fluorouracil, a pyrimidine antimetabolite, which is metabolised into 5-fluoro-2′-deoxyuridine-5′monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). Here are some key points about it:
- Uses: Xitabin is indicated for the treatment of metastatic breast cancer and colon cancer. It is also used for colorectal cancer, breast cancer, pancreatic cancer, and oesophagogastric cancer.
- How it works: FdUMP covalently binds to thymidylate synthase, inhibiting the formation of thymidilate, thus interfering with DNA synthesis. Additionally, FUTP interferes with RNA synthesis.
- Dosage: The dosage varies depending on the condition being treated and the patient’s response to the medication.
- Precautions: Xitabin should only be initiated in a healthcare setting by healthcare providers prepared to manage anaphylaxis that can be life-threatening.
Please note that this information is intended to be used as a guide and does not replace professional medical advice. Always consult with a healthcare professional before starting any new medication.
